Cyclic AMP-responsive element binding protein1 (CREB1) has multiple functions in gene regulation.Various studies have reported that CREB1-dependent gene induction is necessary for memory formation and long-lasting behavioral changes in both vertebrates and invertebrates.In the present study, we characterized Lymnaea CREB1 (LymCREB1) mRNA isoforms o
Objectives: The aim of this study was to assess cyber-user awareness of human infections with avian influenza A H7N9 in Zhejiang, China.Methods: Daily Baidu index values were compared for different keywords, different periods (epidemic and non-epidemic), different levels of epidemic publicity (whether new cases were publicized), and different citie
BackgroundCancer-associated fibroblasts (CAFs) are essential tumoral components of gastric cancer (GC), contributing to the development, therapeutic resistance and immune-suppressive tumor microenvironment (TME) of GC.This study aimed to explore the factors related to matrix CAFs and establish a CAF model to evaluate the prognosis and therapeutic e
Coral microbiomes are critical to holobiont health and functioning, but the stability of host–microbial interactions is fragile, easily shifting from eubiosis to dysbiosis.The heat-induced breakdown of the symbiosis between the host and its dinoflagellate algae (that is, “bleaching”), is one of the most devastating outcomes for reef ecosystem
Histone lysine specific demethylase 1 (LSD1) has been recognized as an important modulator in post-translational process in epigenetics.Dysregulation of LSD1 has been implicated in the development of various cancers.Herein, we report the discovery of the hit Mustard compound 8a (IC50 = 3.93 μmol/L) and further medicinal chemistry efforts, leadin